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Lupus nephritis

Mesenchymal stromal cells in lupus nephritis

Nature Reviews Nephrology volume 13, pages 452–453 (2017)Cite this article

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Immunomodulatory treatment with mesenchymal stromal cells represents a novel therapeutic modality for immune-mediated kidney injury, including in the settings of renal transplantation and glomerulonephritis. A new study illustrates the complexity of aligning clinical trial design, manufacturing and availability of biomarkers in order to turn this promising concept into a therapeutic reality.

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Figure 1: Putative immunomodulatory mechanism of action of mesenchymal stromal cells (MSCs).

References

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Authors and Affiliations

  1. Department of Immunohaematology and Blood Transfusion,

    Willem E. Fibbe

  2. Department of Medicine, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, Netherlands

    Ton J. Rabelink

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  1. Willem E. Fibbe
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  2. Ton J. Rabelink
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Correspondence to Willem E. Fibbe.

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The authors declare no competing financial interests.

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Fibbe, W., Rabelink, T. Mesenchymal stromal cells in lupus nephritis. Nat Rev Nephrol 13, 452–453 (2017). https://doi.org/10.1038/nrneph.2017.100

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