The year 2015 has seen great progress in the renal fibrosis field, as key studies began to build a consensus on the importance of epithelial-to-mesenchymal transition, cell cycle arrest, and defective metabolism in the pathogenesis of kidney fibrosis. New findings also point to a role of developmental signalling in renal fibrogenesis.
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Acknowledgements
The author's work is supported by NIH grants DK064005, DK091239 and DK106049, and National Science of Foundation of China grants 81130011 and 81521003.
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Zhou, D., Liu, Y. Understanding the mechanisms of kidney fibrosis. Nat Rev Nephrol 12, 68–70 (2016). https://doi.org/10.1038/nrneph.2015.215
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DOI: https://doi.org/10.1038/nrneph.2015.215
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