BMP, FGF, and WNT signalling regulate self-renewal of nephron progenitor cells (NPCs). A molecular analysis by Muthukrishnan et al. to delineate these pathways found that BMP7 activates TAK1 and JNK, resulting in JUN phosphorylation, Myc and Ccnd1 transcriptional regulation, and NPC proliferation. JUN is regulated by BMP7, whereas its partner FOS is regulated by FGF9. The researchers show that BMP7 and FGF9 both regulate AP-1 transcription, cell cycle progression, and NPC proliferation, and highlight the cooperation between these two NPC self-renewal pathways.
References
Muthukrishnan, S. D. et al. Concurrent BMP7 and FGF9 signalling governs AP-1 function to promote self-renewal of nephron progenitor cells. Nat. Commun. http://dx.doi.org/10.1038/ncomms10027
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Edwards, J. Promotion of nephron progenitor cell self-renewal. Nat Rev Nephrol 12, 62 (2016). https://doi.org/10.1038/nrneph.2015.213
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DOI: https://doi.org/10.1038/nrneph.2015.213
