Systemic lupus erythematosus (SLE) is a clinically and genetically heterogeneous disease. A recent genome-wide association study, which included 7,219 patients, identified 43 susceptibility loci for SLE, including 10 new associations. As transcription factors were over-represented among the SLE susceptibility genes, the researchers state that their data supports the hypothesis that aberrantly regulated gene expression networks in innate and adaptive immune cells contribute to the risk of developing this disease.
References
Bentham, J. et al. Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus. Nat. Genet. 10.1038/ng.3434
Rights and permissions
About this article
Cite this article
Carney, E. Aberrant regulation of gene expression in systemic lupus erythematosus. Nat Rev Nephrol 12, 2 (2016). https://doi.org/10.1038/nrneph.2015.186
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrneph.2015.186
