New data show that patients with true treatment-resistant hypertension had lower systolic and diastolic blood pressures after 6 months of adjusted drug therapy (n = 10) than those treated with renal denervation with the Symplicity Catheter System (n = 9). Absolute changes in systolic blood pressure were also higher in the drug therapy group. The results call into question the use of surgical renal denervation to lower blood pressures in these patients, but require validation in a larger cohort.