Immunosuppressive drugs commonly used in transplantation and autoimmune diseases are unfortunately associated with increased cancer incidence. Now, a new study reports a direct relationship between the number of regulatory T cells in the blood and the risk of developing invasive skin cancer in kidney transplant recipients.
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As a prognostic biomarker of clear cell renal cell carcinoma RUFY4 predicts immunotherapy responsiveness in a PDL1-related manner
Cancer Cell International Open Access 08 February 2022
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Acknowledgements
The author's work is supported by NIH grant AI096553 and the Frank and Athena Sarris Chair in Transplantation Biology.
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Lakkis, F. TREG cells in transplantation—a double-edged sword?. Nat Rev Nephrol 10, 185–186 (2014). https://doi.org/10.1038/nrneph.2014.35
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DOI: https://doi.org/10.1038/nrneph.2014.35
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