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Immunology

TREG cells in transplantation—a double-edged sword?

Immunosuppressive drugs commonly used in transplantation and autoimmune diseases are unfortunately associated with increased cancer incidence. Now, a new study reports a direct relationship between the number of regulatory T cells in the blood and the risk of developing invasive skin cancer in kidney transplant recipients.

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Acknowledgements

The author's work is supported by NIH grant AI096553 and the Frank and Athena Sarris Chair in Transplantation Biology.

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Correspondence to Fadi G. Lakkis.

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Lakkis, F. TREG cells in transplantation—a double-edged sword?. Nat Rev Nephrol 10, 185–186 (2014). https://doi.org/10.1038/nrneph.2014.35

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