Induction of diabetes in wild-type mice has revealed increased levels of angiotensin coverting enzyme 2 (ACE2), which is involved in regulation of the renin–angiotensin–aldosterone system. Diabetes in these animals led to increases in tubular pressure, hyperfiltration and renal hypertrophy. ACE2-knockout mice and those given ACE2 inhibitors resisted this phenotype, and did not have increased creatinine clearance despite a high-protein diet—implicating ACE2 in diabetic nephropathy.
References
Tikellis, C. et al. Angiotensin converting enzyme 2 and hyperfiltration associated with diabetes. Am. J. Physiol. Renal Physiol. 10.1152/ajprenal.00264.2013
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ACE2 overactivity and hyperfiltration in diabetic nephropathy. Nat Rev Nephrol 10, 182 (2014). https://doi.org/10.1038/nrneph.2014.25
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DOI: https://doi.org/10.1038/nrneph.2014.25