A study in >1,000 men (mean age 70 years) has confirmed that insulin sensitivity indices (ISIs) perform similarly in those with or without chronic kidney disease. Of the ISIs, oral glucose tolerance tests performed better than fasting measurements compared with hyperinsulinaemaic euglycaemic glucose clamp (HEGC; the gold-standard measurement of glucose disposal), which is not subject to renal function bias. Furthermore, neither HEGC nor the ISIs were associated with mortality in this study, regardless of kidney function. Accordingly, kidney function might be independent of insulin sensitivity-related outcomes.
References
Jia, T. et al. Validation of insulin sensitivity surrogate indices and prediction of clinical outcomes in individuals with and without impaired renal function. Kidney Int. 10.1038/ki.2014.1
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Indices of insulin sensitivity put to the test. Nat Rev Nephrol 10, 182 (2014). https://doi.org/10.1038/nrneph.2014.24
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DOI: https://doi.org/10.1038/nrneph.2014.24
