The role of the innate immune system in mediating allograft rejection is unclear. A new study demonstrates for the first time the ability of allografts to stimulate the differentiation of monocytes into inflammatory dendritic cells, which produce IL-12 and stimulate T cells, leading to graft rejection.
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Nayak, D., Mohanakumar, T. Recognizing self versus non-self: new territory for monocytes. Nat Rev Nephrol 10, 548–549 (2014). https://doi.org/10.1038/nrneph.2014.144
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DOI: https://doi.org/10.1038/nrneph.2014.144