New findings suggest that the oncogenic microRNA cluster, miRNA-17∼92, promotes the growth of kidney cysts in mouse models of polycystic kidney disease (PKD). Patel et al. found that miRNA-17∼92 is upregulated in mice with PKD. Kidney-specific overexpression of the cluster induced kidney cysts, whereas kidney-specific inactivation in a model of PKD slowed cyst growth, improved renal function, and prolonged survival. The researchers suggest that miRNA-17∼92 mediates these effects by stimulating proliferation and by repressing Pkd1 and Pkd2.
ORIGINAL RESEARCH PAPER
Patel, V. et al. miR-17∼92 miRNA cluster promotes kidney cyst growth in polycystic kidney disease. Proc. Natl Acad. Sci. USA doi:10.1073/pnas.1301693110
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Pathogenic role for microRNA cluster in PKD. Nat Rev Nephrol 9, 433 (2013). https://doi.org/10.1038/nrneph.2013.121
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DOI: https://doi.org/10.1038/nrneph.2013.121
