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Should we use fibrates in patients with diabetes and mild CKD?

Recent analyses from the FIELD randomized trial of fenofibrate in type 2 diabetes mellitus suggests that fibrates have beneficial effects and are safe in patients with moderate renal impairment. However, too few participants with chronic kidney disease were included in the study to provide reliable information.

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References

  1. Levey, A. S. & Coresh, J. Chronic kidney disease. Lancet 379, 165–180 (2012).

    Article  Google Scholar 

  2. Ting, R. D. et al. Benefits and safety of long-term fenofibrate therapy in people with type 2 diabetes and renal impairment. Diabetes Care 35, 218–225 (2012).

    Article  CAS  Google Scholar 

  3. Keech, A. C. et al. Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): randomised controlled trial. Lancet 366, 1849–1861 (2005).

    Article  CAS  Google Scholar 

  4. The FIELD study investigators. The need for a large-scale trial of fibrate therapy in diabetes: the rationale and design of the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study. Cardiovasc. Diabetol. 3, 9 (2004).

  5. Ansquer, J. C. et al. Effect of fenofibrate on kidney function: a 6-week randomized crossover trial in healthy people. Am. J. Kidney Dis. 51, 904–913 (2008).

    Article  CAS  Google Scholar 

  6. Davis, T. M. et al. Effects of fenofibrate on renal function in patients with type 2 diabetes mellitus: the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study. Diabetologia 54, 280–290 (2011).

    Article  CAS  Google Scholar 

  7. The ACCORD study group. Effects of combination lipid therapy in type 2 diabetes mellitus. N. Engl. J. Med. 362, 1563–1574 (2010).

  8. Jun, M. et al. Effects of fibrates on cardiovascular outcomes: a systematic review and meta-analysis. Lancet 375, 1875–1884 (2010).

    Article  CAS  Google Scholar 

  9. Cholesterol Treatment Trialists' (CTT) Collaboration. Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials. Lancet 376, 1670–1681 (2010).

  10. Baigent, C. et al. The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection): a randomised placebo-controlled trial. Lancet 377, 2181–2192 (2011).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Christoph Wanner.

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Lewis, D., Wanner, C. Should we use fibrates in patients with diabetes and mild CKD?. Nat Rev Nephrol 8, 201–202 (2012). https://doi.org/10.1038/nrneph.2012.37

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