The use of statins as a line of primary prevention in individuals at low risk of cardiovascular events is an area of debate. The most recent meta-analysis from the Cholesterol Treatment Trialists' (CTT) Collaboration suggests that present guidelines for prescribing statin therapy may need to be reconsidered.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Cholesterol Treatment Trialists' Collaboration. Protocol for a prospective collaborative overview of all current and planned randomized trials of cholesterol treatment regimens. Cholesterol Treatment Trialists' (CTT) Collaboration. Am. J. Cardiol. 75, 1130–1134 (1995).
Cholesterol Treatment Trialists' Collaboration. The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials. Lancet http://dx.doi.org/10.1016/S0140-6736(12)60367-5.
Taylor, F. et al. Statins for the primary prevention of cardiovascular disease. Cochrane Database of Systematic Reviews, Issue 1. Art. No.: CD004816 (2011). http://dx.doi.org/10.1002/14651858.CD004816.pub4.
Ray, K. K. et al. Statins and all-cause mortality in high-risk primary prevention: a meta-analysis of 11 randomized controlled trials involving 65,229 participants. Arch. Intern. Med. 170, 1024–1031 (2010).
Tonelli, M. et al. Efficacy of statins for primary prevention in people at low cardiovascular risk: a meta-analysis. CMAJ 183, E1189–E1202 (2011).
Baigent, C. et al. The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection): a randomised placebo-controlled trial. Lancet 377, 2181–2192 (2011).
Wanner, C. et al. Atorvastatin in patients with type 2 diabetes mellitus undergoing hemodialysis. N. Engl. J. Med. 353, 238–248 (2005).
Fellstrom, B. C. et al. Rosuvastatin and cardiovascular events in patients undergoing hemodialysis. N. Engl. J. Med. 360, 1395–1407 (2009).
Navaneethan, S. D., Hegbrant, J. & Strippoli, G. F. Role of statins in preventing adverse cardiovascular outcomes in patients with chronic kidney disease. Curr. Opin. Nephrol. Hypertens. 20, 146–152 (2011).
Ridker, P. M. et al. Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein. N. Engl. J. Med. 359, 2195–2207 (2008).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Jablonski, K., Chonchol, M. Should statin therapy be expanded in patients with CKD?. Nat Rev Nephrol 8, 440–441 (2012). https://doi.org/10.1038/nrneph.2012.142
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrneph.2012.142
This article is cited by
-
Raising awareness of acute kidney injury: a global perspective of a silent killer
Kidney International (2013)