Kidney podocytes are thought to lack much regenerative capacity. However, a new study reports that mature podocytes can reversibly enter the cell cycle and that the Wnt and telomerase pathways are crucial in podocyte proliferation and disease. Shkreli et al. came to these conclusions from studying mice in which the telomerase protein component TERT was conditionally expressed.
ORIGINAL RESEARCH PAPER
Shkreli, M. et al. Reversible cell-cycle entry in adult kidney podocytes through regulated control of telomerase and Wnt signaling. Nat. Med. doi:10.1038/nm.2550
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Mature podocytes can reversibly enter the cell cycle. Nat Rev Nephrol 8, 63 (2012). https://doi.org/10.1038/nrneph.2011.207
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DOI: https://doi.org/10.1038/nrneph.2011.207