General severity of illness scores lack high predictive accuracy for mortality in patients with acute kidney injury (AKI). Using the Veterans Affairs/National Institutes of Health Acute Renal Failure Trial Network database, Demirjian et al. identified 21 independent predictors of mortality and developed an accurate scoring system for outcomes in patients with AKI requiring renal replacement therapy.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
VA/NIH Acute Renal Failure Trial Network. Intensity of renal support in critically ill patients with acute kidney injury. N. Engl. J. Med. 359, 7–20 (2008).
Demirjian, S. et al. Model to predict mortality in critically ill adults with acute kidney injury. Clin. J. Am. Soc. Nephrol. 6, 2114–2120 (2011).
Costa e Silva, V. T. et al. Performance of the third generation models of severity scoring systems (APACHE IV, SAPS 3 and MPM-III) in acute kidney injury critically ill patients. Nephrol. Dial. Transplant. http://dx.doi.org/10.1093/ndt/gfr201.
Faubel, S. Pulmonary complications after acute kidney injury. Adv. Chronic Kidney Dis. 15, 284–296 (2008).
Gartman, E. J., Casserly, B. P., Martin, D. & Ward, N. S. Using serial severity scores to predict death in ICU patients: a validation study and review of the literature. Curr. Opin. Crit. Care 15, 578–582 (2009).
Warren, H. S., Suffredini, A. F., Eichacker, P. Q. & Munford, R. S. Risks and benefits of activated protein C treatment for severe sepsis. N. Engl. J. Med. 347, 1027–1030 (2002).
Bernard, G. R. et al. Efficacy and safety of recombinant human activated protein C for severe sepsis. N. Engl. J. Med. 344, 699–709 (2001).
Schiffl, H., Lang, S. M. & Fischer, R. Daily hemodialysis and the outcome of acute renal failure. N. Engl. J. Med. 346, 305–310 (2002).
Ronco, C. et al. Effects of different doses in continuous veno-venous haemofiltration on outcomes of acute renal failure: a prospective randomised trial. Lancet 356, 26–30 (2000).
Bellomo, R. et al. Intensity of continuous renal-replacement therapy in critically ill patients. N. Engl. J. Med. 361, 1627–1638 (2009).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Faubel, S., Edelstein, C. Severity of illness scoring systems in acute kidney injury. Nat Rev Nephrol 8, 8–10 (2012). https://doi.org/10.1038/nrneph.2011.173
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrneph.2011.173
