The possible cardioprotective and renoprotective effects of statins in patients with chronic kidney disease remain an unsolved enigma for clinicians and researchers in the field of nephrology. Do the recently published AURORA and JUPITER studies shed light on this controversy?
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Sarnak, M. J. et al. Kidney disease as a risk factor for development of cardiovascular disease: a statement from the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention. Circulation 108, 2154–2169 (2003).
Fellstrom, B. C. et al. Rosuvastatin and cardiovascular events in patients undergoing hemodialysis. N. Engl. J. Med. 360, 1395–1407 (2009).
Ridker, P. M., MacFadyen, J., Cressman, M. & Glynn, R. J. Efficacy of rosuvastatin among men and women with moderate chronic kidney disease and elevated high-sensitivity C-reactive protein: a secondary analysis from the JUPITER (Justification for the Use of Statins in Prevention-an Intervention Trial Evaluating Rosuvastatin) trial. J. Am. Coll. Cardiol. 55, 1266–1273 (2010).
Wanner, C. et al. Atorvastatin in patients with type 2 diabetes mellitus undergoing hemodialysis. N. Engl. J. Med. 353, 238–248 (2005).
Kassimatis, T. I. & Konstantinopoulos, P. A. The role of statins in chronic kidney disease (CKD): friend or foe? Pharmacol. Ther. 122, 312–323 (2009).
Kassimatis, T. I. & Konstantinopoulos, P. A. Rosuvastatin in patients undergoing hemodialysis. N. Engl. J. Med. 361, 93; author reply 94–95 (2009).
Strippoli, G. F. & Craig, J. C. Sunset for statins after AURORA? N. Engl. J. Med. 360, 1455–1457 (2009).
Navaneethan, S. D. et al. HMG CoA reductase inhibitors (statins) for people with chronic kidney disease not requiring dialysis. Cochrane Database of Systematic Reviews, Issue 2, Art. No.: CD007784. doi:10.1002/14651858.CD007784 (2009).
Kassimatis, T. I. & Goldsmith, D. J. New hope for CKD patients after JUPITER: myth or reality? J. Am. Coll. Cardiol. doi:10.1016/j.jacc.2010.04.027.
Baigent, C. & Landry, M. Study of Heart and Renal Protection (SHARP). Kidney Int. Suppl. S207–S210 (2003).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Kassimatis, T., Agrafiotis, A. Implications of the AURORA and JUPITER results. Nat Rev Nephrol 6, 636–637 (2010). https://doi.org/10.1038/nrneph.2010.126
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrneph.2010.126
