Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Transplantation

Cytomegalovirus prophylaxis: how long is enough?

Extending the duration of cytomegalovirus prophylaxis to 6 months in virus-seronegative organ recipients who receive transplants from seropositive donors decreases the risk of cytomegalovirus disease. But is prophylaxis extension the best approach to preventing late-onset cytomegalovirus disease?

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Luan, F. L. et al. Six-month prophylaxis is cost effective in transplant patients at high risk for cytomegalovirus infection. J. Am. Soc. Nephrol. 20, 2449–2458 (2009).

    Article  Google Scholar 

  2. Paya, C. et al. Efficacy and safety of valganciclovir vs. oral ganciclovir for prevention of cytomegalovirus disease in solid organ transplant recipients. Am. J. Transplant. 4, 611–620 (2004).

    Article  CAS  Google Scholar 

  3. Humar, A. et al. The IMPACT Study: Valganciclovir prophylaxis for until 200 days post-transplant in high risk kidney recipients substantially reduces the incidence of CMV disease [abstract]. Presented at the American Transplant Congress 2009.

  4. Boivin, G. et al. Absence of cytomegalovirus-resistance mutations after valganciclovir prophylaxis, in a prospective multicenter study of solid-organ transplant recipients. J. Infect. Dis. 189, 1615–1618 (2004).

    Article  CAS  Google Scholar 

  5. Humar, A. et al. Clinical utility of cytomegalovirus (CMV) serology testing in high-risk CMV D+/R- transplant recipients. Am. J. Transplant. 5, 1065–1070 (2005).

    Article  Google Scholar 

  6. Emery, V. C. et al. Application of viral-load kinetics to identify patients who develop cytomegalovirus disease after transplantation. Lancet 355, 2032–2036 (2000).

    Article  CAS  Google Scholar 

  7. Kumar, D. et al. Cell-mediated immunity to predict cytomegalovirus disease in high-risk organ transplant recipients. Am. J. Transplant. 9, 1214–1222 (2009).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Atul Humar.

Ethics declarations

Competing interests

D. Kumar declares association with the following companies: Roche and Cellestis, as recipient of grant/research support. A. Humar declares association with the following companies: Roche, as recipient of speakers bureau (honoraria) and grant/research support, Cellestis, as recipient of grant/research support, and ViroPharma, as recipient of speakers bureau (honoraria).

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kumar, D., Humar, A. Cytomegalovirus prophylaxis: how long is enough?. Nat Rev Nephrol 6, 13–14 (2010). https://doi.org/10.1038/nrneph.2009.207

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrneph.2009.207

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing