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Coordination between RAB GTPase and phosphoinositide regulation and functions

Nature Reviews Molecular Cell Biology volume 13, pages 463–470 (2012)Cite this article

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Abstract

Membrane trafficking relies on dynamic changes in membrane identities that are determined by the regulation of distinct RAB GTPases and phosphoinositides. RABs and phosphoinositides both act to spatiotemporally recruit effectors of membrane remodelling, including sequential RAB and phosphoinositide activities. New ideas on coordinated regulation of specific RABs and phosphoinositides, achieved by direct physical and functional interactions between their regulatory enzymes, are emerging as a central mechanism to ensure precision and fidelity of membrane trafficking.

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Figure 1: Common themes between RAB and phosphoinositide localizations, regulation and functions.
Figure 2: Shared themes in cascading RAB and phosphoinositide pathways.
Figure 3: Interrelationships between RABs and phosphoinositides.

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  1. Steve Jean and Amy A. Kiger are at the Section of Cell and Developmental Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0380, USA.,

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Jean, S., Kiger, A. Coordination between RAB GTPase and phosphoinositide regulation and functions. Nat Rev Mol Cell Biol 13, 463–470 (2012). https://doi.org/10.1038/nrm3379

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