●Focus on signalling and adhesion Nature Cell Biology April (2002) Includes the following articles: Networks and crosstalk: integrin signalling spreads. Schwartz, M. A. & Ginsberg, M. H. Adhesion assembly, disassembly and turnover in migrating cells — over and over again. Webb, D. J., Parsons, J. T. & Horwitz, A. F. Herpesvirus hijacks an integrin. Nemerow, G. R. and Cheresh, D. A.

●A season for midwinter immunology. Sprent, J., Uittenbogaart, C. H. & Fink, P. J. Nature Immunology May (2002) A report on the recent 41st Annual Midwinter Immunology Conference on Immune-System Development and Function.

●Taking a bite: proteasomal protein processing. Jentsch, S. Nature Cell Biology May (2002)

●Neuropilin-1: another neuronal molecule in the “immunological synapse”. Wülfing, C. & Rupp, F. Nature Immunology May (2002) This News and Views article discusses recent work that shows that neuropilin-1, a neuronal receptor, is essential for the initiation of an immune response.

●Papillomaviruses and cancer: from basic studies to clinical application. zur Hausen, H. Nature Reviews Cancer May (2002)

●AIDS-related malignancies. Boshoff, C. & Weiss, R. Nature Reviews Cancer May (2002) Most cancers that are associated with HIV infection are driven by oncogenic viruses — such as Epstein–Barr virus, Kaposi's sarcoma-associated herpesvirus and human papillomavirus. This Review article discusses how insights into the epidemiology of AIDS-related cancers and the mechanisms that underlie them have provided a better understanding of cancer immunity and viral oncogenesis.

●AP-1 as a regulator of cell life and death. Karin, M. Nature Cell Biology May (2002)

●DNA drives autoimmunity. Vinuesa, C. G. & Goodnow, C. C. Nature 11 April (2002) This News and Views article discusses the recent finding that DNA–autoantigen complexes activate autoreactive B cells by co-ligating the B-cell receptor and a Toll-like receptor.

●Structural mechanisms of costimulation. Schwartz, J.-C. D., Zhang, X., Nathenson, S. G. & Almo, S. C. Nature Immunology May (2002)

●New therapeutics that modulate chemokine networks. Schwarz, M. K. & Wells, T. N. C. Nature Reviews Drug Discovery May (2002) Chemokines are small cytokines that have a wide variety of functions. This Review discusses how the pharmacological control of chemokines, or their receptors, could have important therapeutic implications for the treatment of diseases ranging from cancer to infections.