The phenotype and behaviour of primary tumours in the liver is widely believed to reflect their cell of origin. A new study in mice shows that this relationship is not always the case—the cells of origin of intrahepatic cholangiocarcinomas might be hepatocytes rather than the expected cholangiocytes or bipotential hepatic progenitor cells.
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Alison, M., Lin, WR. Intrahepatic cholangiocarcinoma—appearances can be deceiving. Nat Rev Gastroenterol Hepatol 10, 131–133 (2013). https://doi.org/10.1038/nrgastro.2012.258
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DOI: https://doi.org/10.1038/nrgastro.2012.258
