Falls in cirrhosis may result from decreased muscle strength, unsuspected subcortical pathologies or psychoactive medications. Results of a prospective study reveal that cognitive dysfunction assessed by psychometric testing predicts the risk of falls in patients with cirrhosis. Early screening and effective preventive measures are required to limit the costs of falls in this population of patients.
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References
Diamond, T. et al. Osteoporosis and skeletal fractures in chronic liver disease. Gut 1, 82–87 (1990).
Román, E. et al. Minimal hepatic encephalopathy is associated with falls. Am. J. Gastroenterol. 106, 476–482 (2011).
Soriano, G. et al. Cognitive dysfunction in cirrhosis is associated with falls. A prospective study. Hepatology http://dx.doi.org/10.1002/hep.25554.
Weissenborn, K., Ennen, J. C., Schomerus, H., Ruckert, N. & Hecker, H. Neuropsychological characterization of hepatic encephalopathy. J. Hepatol. 34, 768–773 (2001).
Lockwood, A. H., Weissenborn, K., Bokemeyer, M., Tietge, U. & Burchert, W. Correlations between cerebral glucose metabolism and neuropsychological test performance in nonalcoholic cirrhotics. Metab. Brain Dis. 17, 29–40 (2002).
Burkhard, P. R., Delavelle, J., Du, P. R. & Spahr, L. Chronic parkinsonism associated with cirrhosis: a distinct subset of acquired hepatocerebral degeneration. Arch. Neurol. 60, 521–528 (2003).
Spahr, L. et al. Increased blood manganese in cirrhotic patients: relationship to pallidal magnetic resonance signal hyperintensity and neurological symptoms. Hepatology 24, 1116–1120 (1996).
Kril, J. J. & Butterworth, R. F. Diencephalic and cerebellar pathology in alcoholic and nonalcoholic patients with end-stage liver disease. Hepatology 26, 837–841 (1997).
Pepersack, T. et al. Clinical relevance of thiamine status amongst hospitalized elderly patients. Gerontology 45, 96–101 (1999).
van de Warrenburg, B. P., Steijns, J. A., Munneke, M., Kremer, B. P. & Bloem, B. R. Falls in degenerative cerebellar ataxias. Mov. Disord. 20, 497–500 (2005).
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Butterworth, R. Risk of falls in cirrhosis predicted by psychometric testing. Nat Rev Gastroenterol Hepatol 9, 197–198 (2012). https://doi.org/10.1038/nrgastro.2012.22
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DOI: https://doi.org/10.1038/nrgastro.2012.22
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