Burza and colleagues performed a matched, prospective, controlled, interventional trial to investigate the association of the PNPLA3 I148M genetic variant with hepatocellular carcinoma in obese individuals. The study included a cohort of patients undergoing bariatric surgery (surgery group) or receiving conventional treatment (control group). A significantly higher incidence of hepatocellular carcinoma in individuals carrying the PNPLA3 I148M genetic variant was found in the control group.
ORIGINAL RESEARCH PAPER
Burza, M. A. et al. PNPLA3 I148M (rs738409) genetic variant is associated with hepatocellular carcinoma in obese individuals. Dig. Liver Dis. doi:10.1016/j.did.2012.05.006
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Hepatocellular carcinoma, obesity and the PNPLA3 I148M genetic variant. Nat Rev Gastroenterol Hepatol 9, 426 (2012). https://doi.org/10.1038/nrgastro.2012.129
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DOI: https://doi.org/10.1038/nrgastro.2012.129