A new study explores the use of liver biopsy to differentiate drug-induced liver injury (DILI) from autoimmune hepatitis. However, not all that glitters is necessarily the gold standard—disagreement among experts on the histological features of DILI could create uncertainty over the accuracy of this diagnostic approach.
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References
Danan, G. & Benichou, C. Causality assessment of adverse drug reactions to drugs–I. A novel method based on the conclusions of international consensus meetings: application to drug-induced liver injuries. J. Clin. Epidemiol. 46, 1323–1330 (1993).
Suzuki, A. et al. The use of liver biopsy evaluation in discrimination of idiopathic autoimmune hepatitis versus drug-induced liver injury. Hepatology doi:10.1002/hep.24481.
Rockey, D. C. et al. Causality assessment in drug-induced liver injury using a structured expert opinion process: comparison to the Roussel–Uclef causality assessment method. Hepatology 51, 2117–2126 (2010).
Benichou, C., Danan, G. & Flahault, A. Causality assessment of adverse reactions to drugs–II. An original model for validation of drug causality assessment methods: case reports with positive rechallenge. J. Clin. Epidemiol. 46, 1331–1336 (1993).
Shapiro, M. A. & Lewis, J. H. Causality assessment of drug-induced hepatotoxicity: promises and pitfalls. Clin. Liver Dis. 11, 477–505 (2007).
Teshale, E. H., Hu, D. J. & Holmberg, S. D. The two faces of hepatitis E virus. Clin. Infect. Dis. 51, 328–334 (2010).
Kleiner, D. E. The pathology of drug-induced liver injury. Semin. Liver Dis. 29, 364–372 (2009).
Russo, M. W., Scobey, M. & Bonkovsky, H. L. Drug-induced liver injury associated with statins. Semin. Liver Dis. 29, 412–422 (2009).
Liss, G., Rattan, S. & Lewis, J. H. Predicting and preventing acute drug-induced liver injury: what's new in 2010? Expert Opin. Drug Metab. Toxicol. 6, 1047–1061 (2010).
Fontana, R. J. et al. Standardization of nomenclature and causality assessment in drug-induced liver injury: summary of a clinical research workshop. Hepatology 52, 730–742 (2010).
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Lewis, J. Liver biopsy differentiates DILI from autoimmune hepatitis. Nat Rev Gastroenterol Hepatol 8, 540–542 (2011). https://doi.org/10.1038/nrgastro.2011.140
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DOI: https://doi.org/10.1038/nrgastro.2011.140
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