Evidence from a recent study strongly implicates innate immunity in the etiology of Crohn's disease, with particular focus on impaired secretion of cytokines and chemokines by intestinal macrophages in response to bacterial stimuli. These findings highlight the importance of acute inflammatory responses in the first stages of disease pathogenesis.
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Fava, F., Danese, S. Bacterial clearance in Crohn's disease pathogenesis. Nat Rev Gastroenterol Hepatol 7, 126–128 (2010). https://doi.org/10.1038/nrgastro.2010.1
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DOI: https://doi.org/10.1038/nrgastro.2010.1
