This article reports that the specificity of a yeast cell's response to different environmental stimuli depends on the dynamics of nuclear translocation of a single transcription factor, Msn2. By artificially manipulating the amplitude, frequency and duration of Msn2 nuclear translocation and relating these parameters to the expression of an Msn2-dependent reporter gene in single cells, the authors developed a kinetic model that connects external inputs to differential gene expression via the dynamics of one signalling molecule.
ORIGINAL RESEARCH PAPER
Hao, N. & O'Shea, E. K. Signal-dependent dynamics of transcription factor translocation controls gene expression. Nature Struct. Mol. Biol. 19, 31–36 (2012)
Rights and permissions
About this article
Cite this article
Casci, T. A simple model for ensuring signalling specificity. Nat Rev Genet 13, 74 (2012). https://doi.org/10.1038/nrg3169
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrg3169