Successful management of obesity requires integration of pharmaceutical agents and bariatric surgeries with traditional lifestyle modifications. Notable developments for managing obesity in 2015 included the demonstration of weight-beneficial outcomes for liraglutide and empagliflozin, and the first 5-year follow-up of patients with type 2 diabetes mellitus and obesity randomly assigned to receive bariatric surgery or conventional medical therapy.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Switching from a high-fat cellulose diet to a high-fat pectin diet reverses certain obesity-related morbidities
Nutrition & Metabolism Open Access 06 August 2018
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Moyer, V. A. Screening for and management of obesity in adults: U.S. Preventive Services Task Force recommendation statement. Ann. Intern. Med. 157, 373–378 (2012).
Pi-Sunyer, X. et al. A randomized, controlled trial of 3.0 mg of liraglutide in weight management. N. Engl. J. Med. 373, 11–22 (2015).
Zinman, B. et al. Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes. N. Engl. J. Med. 373, 2117–2128 (2015).
Kim, D. D. et al. Efficacy and safety of beloranib for weight loss in obese adults: a randomized controlled trial. Diabetes Obes. Metab. 17, 566–572 (2015).
Zafgen. Zafgen announces partial clinical hold affecting beloranib trials. [online], (2015).
Mingrone, G. et al. Bariatric-metabolic surgery versus conventional medical treatment in obese patients with type 2 diabetes: 5 year follow-up of an open-label, single-centre, randomised controlled trial. Lancet 386, 964–973 (2015).
Purcell, K. et al. The effect of rate of weight loss on long-term weight management: a randomised controlled trial. Lancet Diabetes Endocrinol. 2, 954–962 (2014).
Johansson, K., Neovius, M. & Hemmingsson, E. Effects of anti-obesity drugs, diet, and exercise on weight-loss maintenance after a very-low-calorie diet or low-calorie diet: a systematic review and meta-analysis of randomized controlled trials. Am. J. Clin. Nutr. 99, 14–23 (2014).
[No authors listed] ReShape and Orbera — two gastric balloon devices for weight loss. Med. Lett. Drugs Ther. 57, 122–123 (2015).
Dietz, W. H. et al. Management of obesity: improvement of health-care training and systems for prevention and care. Lancet 385, 2521–2533 (2015).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
J.B.D. has received research funding and consultancy fees from Allergan and Nestlé Australia, and is a member of the Optifast® Medical Advisory Board of Nestlé Australia and the Medical Advisory Board of NovoNordisk. J.B.D. has also been a consultant for Apollo Endosurgery, Bariatric Advantage, mdBriefcase and Nestec, and received honoraria from Covidien, iNova Pharmaceuticals and Merck Sharp & Dohme.
PowerPoint slides
Rights and permissions
About this article
Cite this article
Dixon, J. Advances in managing obesity. Nat Rev Endocrinol 12, 65–66 (2016). https://doi.org/10.1038/nrendo.2015.221
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrendo.2015.221
This article is cited by
-
Transcriptome of visceral adipose tissue identifies an inflammation-related ceRNA network that regulates obesity
Molecular and Cellular Biochemistry (2022)
-
A Study Examining the Orbera365 Intragastric Balloon Safety and Effects on Weight Loss
Obesity Surgery (2021)
-
Switching from a high-fat cellulose diet to a high-fat pectin diet reverses certain obesity-related morbidities
Nutrition & Metabolism (2018)