A new multi-omics study has revealed genomic alterations that underlie phaeochromocytomas and paragangliomas. The analysis showed that the genetic status of these tumours is strongly correlated with multi-omics data (for example, methylation patterns and microRNA expression profiles). Tumour subtypes can therefore be defined on the basis of a set of genomic alterations. The researchers suggest that omics-based tests will be developed in the future that will enable precise molecular classification of these tumours, paving the way to personalized medicine.
References
Castro-Vega, L. J. et al. Multi-omics analysis defines core genomic alterations in pheochromocytomas and paragangliomas. Nat. Commun. 10.1038/ncomms7044
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Genomics of phaeochromocytomas and paragangliomas. Nat Rev Endocrinol 11, 194 (2015). https://doi.org/10.1038/nrendo.2015.22
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DOI: https://doi.org/10.1038/nrendo.2015.22