Neuroendocrine cancer

Definition

Neuroendocrine cancer (also known as NETs) is a cancer type that arises from cells of the neuroendocrine system (cells that release hormones in our body). They are classified according to where the primary tumour originated from, and the most common types are gastrointestinal, lung or pancreatic NETs.

Latest Research and Reviews

  • Research |

    The genomes of 102 primary pancreatic neuroendocrine tumours have been sequenced, revealing mutations in genes with functions such as chromatin remodelling, DNA damage repair, mTOR activation and telomere maintenance, and a greater-than-expected contribution from germ line mutations.

    • Aldo Scarpa
    • , David K. Chang
    • , Katia Nones
    • , Vincenzo Corbo
    • , Ann-Marie Patch
    • , Peter Bailey
    • , Rita T. Lawlor
    • , Amber L. Johns
    • , David K. Miller
    • , Andrea Mafficini
    • , Borislav Rusev
    • , Maria Scardoni
    • , Davide Antonello
    • , Stefano Barbi
    • , Katarzyna O. Sikora
    • , Sara Cingarlini
    • , Caterina Vicentini
    • , Skye McKay
    • , Michael C. J. Quinn
    • , Timothy J. C. Bruxner
    • , Angelika N. Christ
    • , Ivon Harliwong
    • , Senel Idrisoglu
    • , Suzanne McLean
    • , Craig Nourse
    • , Ehsan Nourbakhsh
    • , Peter J. Wilson
    • , Matthew J. Anderson
    • , J. Lynn Fink
    • , Felicity Newell
    • , Nick Waddell
    • , Oliver Holmes
    • , Stephen H. Kazakoff
    • , Conrad Leonard
    • , Scott Wood
    • , Qinying Xu
    • , Shivashankar Hiriyur Nagaraj
    • , Eliana Amato
    • , Irene Dalai
    • , Samantha Bersani
    • , Ivana Cataldo
    • , Angelo P. Dei Tos
    • , Paola Capelli
    • , Maria Vittoria Davì
    • , Luca Landoni
    • , Anna Malpaga
    • , Marco Miotto
    • , Vicki L. J. Whitehall
    • , Barbara A. Leggett
    • , Janelle L. Harris
    • , Jonathan Harris
    • , Marc D. Jones
    • , Jeremy Humphris
    • , Lorraine A. Chantrill
    • , Venessa Chin
    • , Adnan M. Nagrial
    • , Marina Pajic
    • , Christopher J. Scarlett
    • , Andreia Pinho
    • , Ilse Rooman
    • , Christopher Toon
    • , Jianmin Wu
    • , Mark Pinese
    • , Mark Cowley
    • , Andrew Barbour
    • , Amanda Mawson
    • , Emily S. Humphrey
    • , Emily K. Colvin
    • , Angela Chou
    • , Jessica A. Lovell
    • , Nigel B. Jamieson
    • , Fraser Duthie
    • , Marie-Claude Gingras
    • , William E. Fisher
    • , Rebecca A. Dagg
    • , Loretta M. S. Lau
    • , Michael Lee
    • , Hilda A. Pickett
    • , Roger R. Reddel
    • , Jaswinder S. Samra
    • , James G. Kench
    • , Neil D. Merrett
    • , Krishna Epari
    • , Nam Q. Nguyen
    • , Nikolajs Zeps
    • , Massimo Falconi
    • , Michele Simbolo
    • , Giovanni Butturini
    • , George Van Buren
    • , Stefano Partelli
    • , Matteo Fassan
    • , Australian Pancreatic Cancer Genome Initiative
    • , Kum Kum Khanna
    • , Anthony J. Gill
    • , David A. Wheeler
    • , Richard A. Gibbs
    • , Elizabeth A. Musgrove
    • , Claudio Bassi
    • , Giampaolo Tortora
    • , Paolo Pederzoli
    • , Sean M. Grimmond
    • , John V. Pearson
    • , Andrew V. Biankin
    •  & Nicola Waddell
    Nature 543, 65–71
  • Reviews |

    Childhood-onset craniopharyngioma is a rare embryonic tumour of low-grade malignancy that has traditionally been treated by radical resection. Here, Müller and colleagues review recent advances in the molecular pathogenesis of the disease and treatment strategies that could lead to novel targeted therapies and more-limited surgeries.

    • Hermann L. Müller
    • , Thomas E. Merchant
    • , Stephanie Puget
    •  & Juan-Pedro Martinez-Barbera

News and Comment