Limostatin—a decretin—suppresses insulin production

Experiments in Drosophila melanogaster have revealed that limostatin, a peptide hormone, suppresses insulin production and secretion and can therefore be classed as a decretin hormone. Flies that lacked limostatin displayed features similar to hyperinsulinaemia, hypoglycaemia and increased adiposity. The researchers suggest that neuromedin U receptors are a human orthologue for limostatin, as NMRU1 is expressed in human islet β cells and purified neuromedin U suppressed insulin section in isolated human β cells.