Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Diabetes

Metformin and renal insufficiency—is 45, or even 30, the new 60?

In an analysis of data from NHANES spanning from 1999 to 2010, Tuot et al. address two linked questions. Which patients with diabetes mellitus and renal insufficiency are reasonable candidates for metformin therapy and how does this treatment depend on the approach used to measure renal function?

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. FDA. Metformin hydrochloride tablets [online], (2015).

  2. Tuot, D. S. et al. Potential impact of prescribing metformin according to eGFR rather than serum creatinine. Diabetes Care. http://dx.doi.org/10.2337/dc15-0542.

  3. Kennedy, L. et al. Renal status among patients using metformin in a primary care setting. Diabetes Care 28, 922–924 (2005).

    Article  Google Scholar 

  4. Bloomgarden, Z. Sodium-glucose cotransporter 2 inhibitors and renal function-2. J. Diabetes 7, 295–298 (2015).

    Article  CAS  Google Scholar 

  5. Hung, A. M. et al. Comparative effectiveness of incident oral antidiabetic drugs on kidney function. Kidney Int. 81, 698–706 (2012).

    Article  CAS  Google Scholar 

  6. Boussageon, R. et al. Reappraisal of metformin efficacy in the treatment of type 2 diabetes: a meta-analysis of randomised controlled trials. PLoS Med. 9, e1001204 (2012).

    Article  Google Scholar 

  7. Bloomgarden, Z. Approaches to treatment 1: How is type 2 diabetes actually treated? J. Diabetes http://dx.doi.org/10.1111/1753-0407.12329.

  8. Inzucchi, S. E., Lipska, K. J., Mayo, H., Bailey, C. J. & McGuire, D. K. Metformin in patients with type 2 diabetes and kidney disease: a systematic review. JAMA 312, 2668–2675 (2014).

    Article  Google Scholar 

  9. Hyre, A. D., Fox, C. S., Astor, B. C., Cohen, A. J. & Muntner, P. The impact of reclassifying moderate CKD as a coronary heart disease risk equivalent on the number of US adults recommended lipid-lowering treatment. Am. J. Kidney Dis. 49, 37–45 (2007).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Zachary Bloomgarden.

Ethics declarations

Competing interests

Z.B. has received honoraria from Astra Zeneca, Janssen, Merck and NovoNordisk. Z.B. has also received consulting fees from Amgen, Astra Zeneca, Janssen, Merck, NovoNordisk and Novartis. Z.B. also owns stock holdings in Baxter International, CVS Caremark, Novartis, Roche Holdings and St Jude Medical.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Bloomgarden, Z. Metformin and renal insufficiency—is 45, or even 30, the new 60?. Nat Rev Endocrinol 11, 693–694 (2015). https://doi.org/10.1038/nrendo.2015.166

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrendo.2015.166

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing