Transient expression of a type I interferon (IFN)-inducible gene signature is a risk factor for autoimmunity in children genetically predisposed to develop type 1 diabetes mellitus (T1DM). Microarray analysis was used to define a set of 225 IFN-inducible genes, the expression of which was quantified in 87 healthy controls, 64 individuals with T1DM and 109 children predisposed to develop T1DM IFN-inducible gene expression was found to precede autoantibody development in the latter group, but not in individuals with established disease.
References
Ferreira, R. C. et al. A type I interferon transcriptional signature precedes autoimmunity in children genetically at-risk of type 1 diabetes. Diabetes 10.2337/db13-1777
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A type I interferon expression signature precedes T1DM. Nat Rev Endocrinol 10, 251 (2014). https://doi.org/10.1038/nrendo.2014.33
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DOI: https://doi.org/10.1038/nrendo.2014.33
