In a new study, treatment with dibenzazepine increased the number of GLP-1-producing L cells and stimulated GLP-1 secretion in mouse and human organoid-based cell culture systems. Dibenzazepine treatment was also associated with increased insulin secretion and improved glucose tolerance in a mouse model of type 2 diabetes mellitus (T2DM), effects that were mediated through increased GLP-1 signalling. Increasing the number of L cells in the intestine could be an alternative to GLP-1 therapy in patients with T2DM.
References
Petersen, N. et al. Targeting development of incretin-producing cells increases insulin secretion. J. Clin. Invest. 10.1172/JCI75838
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Increasing the number of intestinal L cells—an alternative to GLP-1 therapy in type 2 diabetes mellitus?. Nat Rev Endocrinol 11, 132 (2015). https://doi.org/10.1038/nrendo.2014.244
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DOI: https://doi.org/10.1038/nrendo.2014.244
