Novel findings shed light on the mechanisms whereby PPARγ agonists, such as rosiglitazone, induce browning of white adipocytes. In human adipocytes, rosiglitazone triggered a specific 'brown-in-white' (brite) adipocyte gene programme that increased mitochondrial oxidative capacity. Browning induced reprogramming of PPARγ binding, with PPARγ 'superenhancers' being associated with the brite-selective programme. KLF11 was identified as a novel transcription factor that is activated by PPARγ and cooperates with it to induce and maintain the brite-selective programme.
References
Loft, A. et al. Browning of human adipocytes requires KLF11 and reprogramming of PPARγ superenhancers. Genes Dev. 10.1101/gad.250829.114
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PPARγ agonists and adipocyte browning—new insights. Nat Rev Endocrinol 11, 132 (2015). https://doi.org/10.1038/nrendo.2014.243
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DOI: https://doi.org/10.1038/nrendo.2014.243
