A GLP-1–estrogen conjugate that enables targeted delivery of estrogen to cells expressing GLP-1 receptors offered more protection against β-cell failure than GLP-1 alone in a study in male New Zealand obese mice, which are prone to developing type 2 diabetes mellitus. GLP-1–estrogen also reduced food intake and weight gain, and improved glucose control and glucose tolerance when compared with GLP-1 alone.
References
Schwenk, R. W. et al. GLP-1–oestrogen attenuates hyperphagia and protects from beta cell failure in diabetes-prone New Zealand obese (NZO) mice. Diabetologia 10.1007/s00125-014-3478-3
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GLP-1–estrogen conjugate superior to GLP-1 alone in decreasing food intake and protecting pancreatic β cells. Nat Rev Endocrinol 11, 132 (2015). https://doi.org/10.1038/nrendo.2014.242
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DOI: https://doi.org/10.1038/nrendo.2014.242
