PPARβ/δ, which regulates lipid metabolism and energy homeostasis, also has a role in bone homeostasis, report Scholtysek and co-workers. In mice deficient in PPARβ/δ, Wnt signalling activity and serum concentrations of osteoprotegerin were reduced, whereas osteoclast numbers and rates of osteopenia were increased. By contrast, in a mouse model of postmenopausal osteoporosis in which PPARβ/δ was pharmacologically activated, bone turnover was rebalanced and bone density was restored to normal. The researchers suggest that PPARβ/δ is a promising target for the treatment of osteoporosis.
ORIGINAL RESEARCH PAPER
Scholtysek, C. et al. PPARβ/δ governs Wnt signaling and bone turnover. Nat. Med. doi:10.1038/nm.3146
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A key role for PPARβ/δ in bone homeostasis. Nat Rev Endocrinol 9, 380 (2013). https://doi.org/10.1038/nrendo.2013.92
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DOI: https://doi.org/10.1038/nrendo.2013.92