The health responses to antenatal vitamin A supplementation evaluated in randomized intervention trials were recently systematically reviewed by van den Broek and colleagues. The importance of this update is reflected in the persistence of vitamin A deficiency during pregnancy and its potential to affect maternal and infant health and survival in many low-income countries.
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References
World Health Organization. Global prevalence of vitamin A deficiency in populations at risk 1995–2005: WHO global database on vitamin A deficiency [online], (2009).
Christian, P. Recommendations for indicators: night blindness during pregnancy—a simple tool to assess vitamin A deficiency in a population. J. Nutr. 132, 2884S–2888S (2002).
Christian, P. et al. Night blindness during pregnancy and subsequent mortality among women in Nepal: Effects of Vitamin A and β-carotene supplementation. Am. J. Epidemiol. 152, 542–547 (2000).
Faisel, H. & Pittrof, R. Vitamin A and causes of maternal mortality: association and biological plausibility. Public Health Nutrition 3, 321–327 (2000).
van den Broek, N. et al. Vitamin A supplementation during pregnancy for maternal and newborn outcomes. Cochrane Database of Systematic Reviews, Issue 11. Art. No.: CD008666. doi:10.1002/14651858.CD008666.pub2 (2010).
West, K. P. Jr et al. Double blind, cluster randomised trial of low dose supplementation with vitamin A or β carotene on mortality related to pregnancy in Nepal. BMJ 318, 570–575 (1999).
Kirkwood, B. R. et al. Effect of vitamin A supplementation in women of reproductive age on maternal survival in Ghana (ObaapaVitA): a cluster-randomised, placebo-controlled trial. Lancet 375, 1640–1649 (2010).
West, K. P. Jr et al. Effect of vitamin A supplementation on maternal survival. Lancet 376, 873–874 (2010).
Katz, J. et al. Maternal low-dose vitamin A or beta-carotene supplementation has no effect on fetal loss and early infant mortality: a randomized cluster trial in Nepal. Am. J. Clin. Nutr. 71, 1570–1576 (2000).
Christian, P. et al. Maternal night blindness increases risk of infant mortality in the first 6 months of life in Nepal. J. Nutr. 131, 1510–1512 (2001).
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Christian, P., West, K. Vitamin A supplementation—maternal and neonatal survival. Nat Rev Endocrinol 7, 190–192 (2011). https://doi.org/10.1038/nrendo.2011.31
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DOI: https://doi.org/10.1038/nrendo.2011.31
