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Integrative knowledge management to enhance pharmaceutical R&D

Nature Reviews Drug Discovery volume 13, pages 239–240 (2014)Cite this article

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Information technologies already have a key role in pharmaceutical research and development (R&D), but achieving substantial advances in their use and effectiveness will depend on overcoming current challenges in sharing, integrating and jointly analysing the range of data generated at different stages of the R&D process.

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References

  1. Sansone, S. A. et al. Toward interoperable bioscience data. Nature Genet. 44, 121–126 (2012).

    Article  CAS  PubMed  Google Scholar 

  2. Cases, M. et al. Improving data and knowledge management to better integrate health care and research. J. Intern. Med. 274, 321–328 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Beck, T. et al. Knowledge engineering for health: a new discipline required to bridge the “ICT gap” between research and healthcare. Hum. Mutat. 33, 797–802 (2012).

    Article  PubMed  Google Scholar 

  4. Kitano, H. et al. Social engineering for virtual 'big science' in systems biology. Nature Chem. Biol. 7, 323–326 (2011).

    Article  CAS  Google Scholar 

  5. Williams, A. J. et al. Open PHACTS: semantic interoperability for drug discovery. Drug Discov. Today 17, 1188–1198 (2012).

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

The debate on “Translational Knowledge Management in Pharmaceutical R&D” was held in Brussels on 11–12 July 2013, within the framework of the European INBIOMEDvision CSA (funded by the EU FP7 under grant agreement no. 270107) and with the collaboration of Innovative Medicines Initiative (IMI). In addition to the authors, A. Martin, R. Bellazzi, N. Blomberg, A. Brookes, R. Campbell, B. de Bono, I. Dix, G. Ecker, Y. Guo, B. Hardy, M. Hofmann-Apitius, J. Houwing-Duistermaat, L. D. Hudson, B. Kisler, J. Kleinjans, V. Maojo, J. Mestres, J.L. Oliveira, M. Pastor, T. Rijnders, S. Scollen, T. Steger-Hartmann, P. Ruch, T. Slater, G. O. Strawn, M. Sundgren, J. van der Lei and M. Goldman were speakers at the debates and are acknowledged for their valuable input and support for the ideas in this paper, which represent the consensus view of all the participants (see Supplementary information S1 (box) for their affiliations).

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Authors and Affiliations

  1. IMIM and Universitat Pompeu Fabra, Dr. Aiguader 88, Barcelona, 08003, Spain

    Maria Marti-Solano & Ferran Sanz

  2. European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, CB10 1SD, Cambridgeshire, UK

    Ewan Birney

  3. Institut de Recherches Internationales Servier, 53 rue Carnot, 92284, Suresnes Cedex, France

    Antoine Bril

  4. GlaxoSmithKline, Stockley Park West, Uxbridge, UB11 1BT, Middlesex, UK

    Oscar Della Pasqua

  5. Systems Biology Institute, 5-6-9 Shirokanedai, Minato, Tokyo 108–0071, Japan; and the RIKEN Center for Integrative Medical Sciences, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama City, Kanagawa 230–0045, Japan.,

    Hiroaki Kitano

  6. and the RIKEN Center for Integrative Medical Sciences, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama City, Kanagawa 230–0045, Japan.,

    Hiroaki Kitano

  7. Netherlands Bioinformatics Centre, 260 NBIC, 6500 HB Nijmegen, The Netherlands; and the Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.,

    Barend Mons

  8. and the Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.,

    Barend Mons

  9. Swiss Institute of Bioinformatics, Quartier Sorge - Batiment Genopode, Lausanne, 1015, Switzerland

    Ioannis Xenarios

Authors
  1. Maria Marti-Solano
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  2. Ewan Birney
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  3. Antoine Bril
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  4. Oscar Della Pasqua
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  5. Hiroaki Kitano
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  6. Barend Mons
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  7. Ioannis Xenarios
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  8. Ferran Sanz
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Corresponding author

Correspondence to Ferran Sanz.

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The authors declare no competing financial interests.

Supplementary information

Supplementary information S1 (box)

Meeting program and affiliations of participants (PDF 127 kb)

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Marti-Solano, M., Birney, E., Bril, A. et al. Integrative knowledge management to enhance pharmaceutical R&D. Nat Rev Drug Discov 13, 239–240 (2014). https://doi.org/10.1038/nrd4290

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