This paper showed that FtsZ, a guanosine triphosphatase involved in bacterial cell division, is a new target for overcoming methicillin-resistant Staphylococcus aureus (MRSA) resistance to β-lactam antibiotics. The authors showed that the FtsZ-specific inhibitor PC190723 acts synergistically with a β-lactam antibiotic to reduce infection in a mouse model of MRSA; these effects were due to the concomitant delocalization of FtsZ and the antibiotic target. Although mutations that conferred resistance to PC190723 were identified, combining PC190723 with a β-lactam antibiotic reduced the frequency and virulence of the MRSA mutants.