●Hormone therapy: A dangerous elixir? Pearson, H. Nature 30 September (2004)

●The CXCL12–CXCR4 chemotactic pathway as a target of adjuvant breast cancer therapies. Epstein, R. J. Nature Reviews Cancer November (2004) This Perspective article discusses the mechanisms and potential advantages of dose-dense adjuvant breast cancer chemotherapy as a new treatment strategy for improving tumour control.

●The price of hope. Chirac, P. Nature 7 October (2004) A review of the book Strong Medicine: Creating Incentives for Pharmaceutical Research on Neglected Diseases by Kremer, M. & Glennerster, R.

●Neurodegenerative diseases: a decade of discoveries paves the way for therapeutic breakthroughs. Forman, M. S., Trojanowski, J. Q. & Lee, V. M. -Y. Nature Medicine October (2004) This Historical Perspective is part of a series of articles that highlight some of the major biomedical achievements of the past decade.

●Exploiting anti-human immunodeficiency virus drugs for tumour therapy. Monini, P., Sgadari, C., Toschi, E., Barillari, G. & Ensoli, B. Nature Reviews Cancer November (2004) Recent evidence indicates that antiretroviral agents that inhibit human immunodeficiency virus (HIV) protease have direct anti-angiogenic and antitumour effects, making them promising candidates for novel cancer therapies both in patients with and without HIV.

●The prediction of disease risk in genomic medicine. Hall, W. D., Morley, K. I. & Lucke, J. C. EMBO Reports October (2004)

●Suppressing the self in rheumatoid arthritis. Mittler, R. S. Nature Medicine October (2004) New work indicating that antibodies that stimulate T-cell co-stimulatory receptors are successful at blocking the progression of rheumatoid arthritis in a mouse model is highlighted in this News and Views article.

●Turning aptamers into anticoagulants. Famulok, M. Nature Biotechnology November (2004)

●Focus on biomanufacturing and bioprocessingNature Biotechnology November (2004) Articles include:

●Biomanufacturing, from bust to boom ... to bubble? Thiel, K. A.

●Biogenerics standoff. Herrera, S.