An observational study of the performance of serum cancer antigen 125 (CA-125), interpreted using the risk of ovarian cancer algorithm, reveals the sensitivity of this approach in women with a high risk of ovarian cancer. In the study cohort consisting of 4,348 women, 19 were diagnosed with ovarian cancer, with a modelled sensitivity of 94%. Six of these diagnoses were of occult disease on follow-up transvaginal sonography, as used in women with a >10% lifetime risk detected during initial screening. 18 of the 19 women diagnosed within 1 year of commencing screening had no residual disease, highlighting the value of early diagnosis.
References
Rosenthal, A. N. et al. Evidence of stage shift in women diagnosed with ovarian cancer during phase II of the United Kingdom Familial Ovarian Cancer Screening Study. J. Clin. Oncol. http://dx.doi.org/10.1200/JCO.2016.69.9330 (2017)
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Sidaway, P. Algorithm enables early detection. Nat Rev Clin Oncol 14, 262 (2017). https://doi.org/10.1038/nrclinonc.2017.37
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DOI: https://doi.org/10.1038/nrclinonc.2017.37