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Small-cell lung cancer in 2016

Shining light on novel targets and therapies

Nature Reviews Clinical Oncology volume 14, pages 75–76 (2017)Cite this article

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In 2016, the pace of biological insights into small-cell lung cancer (SCLC) was reflected in new treatment approaches that have suggested meaningful clinical benefit to patients. We focus on three highlights of 2016: preclinical studies defining NFIB as a putative driver of metastasis, and two clinical studies; one that assessed the efficacy of an agent targeting the Notch ligand DLL3, and the other that explored T-cell checkpoint-blockade therapies targeting PD-1 and CTLA-4.

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Authors and Affiliations

  1. Charles M. Rudin and John T. Poirier are at the Molecular Pharmacology Program and Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA,

    Charles M. Rudin & John T. Poirier

  2. and at the Weill Cornell Medical College, New York, New York, USA.,

    Charles M. Rudin & John T. Poirier

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  1. Charles M. Rudin
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  2. John T. Poirier
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Correspondence to Charles M. Rudin or John T. Poirier.

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Competing interests

C.M.R. has been a paid consultant regarding oncology drug development for BMS, Celgene, Chugai, Harpoon, and Novartis. J.T.P. declares no competing interests.

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Rudin, C., Poirier, J. Shining light on novel targets and therapies. Nat Rev Clin Oncol 14, 75–76 (2017). https://doi.org/10.1038/nrclinonc.2016.203

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