The adverse cardiovascular effects of antipsychotic treatment are well documented, but whether antipsychotic agents can increase the risk of myocardial infarction (MI) remains unclear. Yu et al. performed a systematic review and meta-analysis of nine observational studies comparing the incidence of MI in patients receiving antipsychotic drugs with those who were not receiving treatment. Patients receiving antipsychotic drugs had a 1.88-fold higher risk of developing MI than untreated individuals. Furthermore, short-term use of antipsychotic medication (<30 days) was associated with an even greater risk of MI.