Between June 1999 and January 2004, the COURAGE trial investigators randomly assigned 2,287 patients with stable ischaemic heart disease to an initial management strategy with optimal medical therapy (OMT) only, or OMT plus percutaneous coronary intervention (PCI). After 4.5 years of follow-up, no significant difference was found in the rate of survival between the two groups. The investigators now report extended follow-up data (median duration 11.9 years at sites that permitted survival tracking) in 1,211 of these patients. All-cause mortality remained similar in the two treatment groups (24% vs 25%; HR 1.03, 95% CI 0.83–1.21, P = 0.76).
References
Sedlis, S. P. et al. Effect of PCI on long-term survival in patients with stable ischemic heart disease. N. Engl. J. Med. 373, 1937–1946 (2015)
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Lim, G. Long-term survival after PCI for stable ischaemic heart disease. Nat Rev Cardiol 13, 3 (2016). https://doi.org/10.1038/nrcardio.2015.185
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DOI: https://doi.org/10.1038/nrcardio.2015.185
