The NXT trial supports the value of computational fluid dynamics applied to the digitally reconstructed coronary tree as a noninvasive method of identifying ischaemia-generating stenoses. The results of the study also suggest that old indices of angiographic severity used in clinical practice, such as percent diameter stenosis, might become obsolete.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
van de Hoef, T. P. et al. Fractional flow reserve as a surrogate for inducible myocardial ischaemia. Nat. Rev. Cardiol. 10, 439–452 (2013).
Nørgaard, B. L. et al. Diagnostic performance of non-invasive fractional flow reserve derived from coronary CT angiography in suspected coronary artery disease: the NXT trial. J. Am. Coll. Cardiol. http://dx.doi.org/10.1016/j.jacc.2013.11.043.
Gonzalo, N. et al. Morphometric assessment of coronary stenosis relevance with optical coherence tomography: a comparison with fractional flow reserve and intravascular ultrasound. J. Am. Coll. Cardiol. 59, 1080–1089 (2012).
Kirkeeide, R. L., Gould, K. L. & Parsel, L. Assessment of coronary stenoses by myocardial perfusion imaging during pharmacologic coronary vasodilation. VII. Validation of coronary flow reserve as a single integrated functional measure of stenosis severity reflecting all its geometric dimensions. J. Am. Coll. Cardiol. 7, 103–113 (1986).
Schuleri, K. H., George, R. T. & Lardo, A. C. Applications of cardiac multidetector CT beyond coronary angiography. Nat. Rev. Cardiol. 6, 699–710 (2009).
Koo, B. K. et al. Diagnosis of ischemia-causing coronary stenoses by noninvasive fractional flow reserve computed from coronary computed tomographic angiograms. Results from the prospective multicenter DISCOVER-FLOW (Diagnosis of Ischemia-Causing Stenoses Obtained Via Noninvasive Fractional Flow Reserve) study. J. Am. Coll. Cardiol. 58, 1989–1997 (2011).
Min, J. K. et al. Diagnostic accuracy of fractional flow reserve from anatomic CT angiography. JAMA 308, 1237–1245 (2012).
Blankstein, R. & Di Carli, M. F. Integration of coronary anatomy and myocardial perfusion imaging. Nat. Rev. Cardiol. 7, 226–236 (2010).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing financial interests.
PowerPoint slides
Rights and permissions
About this article
Cite this article
Escaned, J. Can FFRCT replace old indices of coronary stenosis severity?. Nat Rev Cardiol 11, 252–254 (2014). https://doi.org/10.1038/nrcardio.2014.41
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrcardio.2014.41