Coronary artery disease and stable angina

Definition

Coronary artery disease is a pathological condition in which a coronary artery is narrowed or blocked, usually as a result of atherosclerosis. Stable angina, or 'angina pectoris', is the chest pain or discomfort that can result from the impaired blood flow through the blood vessels in the heart muscle, and usually occurs after exercise or stress.

Latest Research and Reviews

  • Reviews | | open

    A range of drugs is available for symptomatic angina, but the optimal choice or combination of therapies is often uncertain, and contemporary guidelines do not necessarily provide definite recommendations. In this Consensus Statement, Ferrari and colleagues propose an individualized approach to angina treatment, which takes into consideration the patient, their comorbidities, and the underlying mechanism of disease.

    • Roberto Ferrari
    • , Paolo G. Camici
    • , Filippo Crea
    • , Nicolas Danchin
    • , Kim Fox
    • , Aldo P. Maggioni
    • , Athanasios J. Manolis
    • , Mario Marzilli
    • , Giuseppe M. C. Rosano
    •  & José L. Lopez-Sendon
  • Research |

    Sekar Kathiresan and colleagues perform a genome-wide association test for coronary artery disease (CAD) using data from the UK Biobank. They identify 15 new loci and perform phenome-wide association scanning, implicating insulin resistance pathways and transendothelial migration of leukocytes in CAD.

    • Derek Klarin
    • , Qiuyu Martin Zhu
    • , Connor A Emdin
    • , Mark Chaffin
    • , Steven Horner
    • , Brian J McMillan
    • , Alison Leed
    • , Michael E Weale
    • , Chris C A Spencer
    • , François Aguet
    • , Ayellet V Segrè
    • , Kristin G Ardlie
    • , Amit V Khera
    • , Virendar K Kaushik
    • , Pradeep Natarajan
    • , CARDIoGRAMplusC4D Consortium
    •  & Sekar Kathiresan
    Nature Genetics 49, 1392–1397
  • Reviews |

    Autophagy is a ubiquitous cellular catabolic process responsive to energy stress. Activation of autophagy is cardioprotective in some settings (ischaemia and ischaemic preconditioning), but sustained autophagy has been linked with cardiopathology in other settings (prolonged pressure overload and heart failure). In this Review, induction of autophagy associated with cardiac benefit or detriment is considered, and prospects for pharmacological intervention are discussed.

    • Lea M. D. Delbridge
    • , Kimberley M. Mellor
    • , David J. Taylor
    •  & Roberta A. Gottlieb
  • Reviews |

    The role of hypertriglyceridaemia as a risk factor for coronary artery disease (CAD) is debated. In this Review, Reiner summarizes the causes of hypertriglyceridaemia, and discusses whether elevated blood triglyceride levels are an important and independent risk factor for CAD. Finally, current and emerging management options for hypertriglyceridaemia are detailed.

    • Željko Reiner

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