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Coronary artery disease

HDL and coronary heart disease—novel insights

Nature Reviews Cardiology volume 11, pages 559–560 (2014)Cite this article

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The association between HDL cholesterol and cardiovascular events, and the potential antiatherogenic effects of HDL particles, are altered in patients with established coronary heart disease. HDL particle composition has, therefore, gained attention after trials of therapies to increase HDL-cholesterol levels did not reduce the risk of an adverse cardiovascular event.

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Figure 1: HDL particles are highly heterogeneous.

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Acknowledgements

U.L. is supported by a grant from the Fondation Leducq, the Swiss National Science Foundation (grant no 310030-149990) and from European-FP7 “Risky CAD”.

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  1. University Heart Center, University Hospital Zurich, Raemistrassse 100, 8091, Zurich, Switzerland

    Ulf Landmesser

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  1. Ulf Landmesser
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Correspondence to Ulf Landmesser.

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Competing interests

U.L. has received research support, honoraria, or consultant fees from Amgen, Astra Zeneca, Merck Sharp & Dohme, Pfizer, Roche, and Sanofi-Aventis.

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Landmesser, U. HDL and coronary heart disease—novel insights. Nat Rev Cardiol 11, 559–560 (2014). https://doi.org/10.1038/nrcardio.2014.128

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