Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Arrhythmias

Cardiac resynchronization therapy in women

Nature Reviews Cardiology volume 11, pages 501–502 (2014)Cite this article

Subjects

A meta-analysis by investigators from FDA of three major trials of cardiac resynchronization therapy (CRT) demonstrated that women have a reduced rate of heart failure (HF) and death with CRT at a shorter QRS duration than men. Recognizing these sex-specific differences is important to improve outcomes for women with HF.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Arshad, A. et al. Cardiac resynchronization therapy is more effective in women than in men. The MADIT-CRT (Multicenter Automatic Defibrillator Implantation Trial With Cardiac Resynchronization Therapy) trial. J. Am. Coll. Cardiol. 57, 813–820 (2011).

    Article  Google Scholar 

  2. Woo, G. W. et al. Ventricular reverse remodeling and 6-month outcomes in patients receiving cardiac resynchronization therapy: analysis of the MIRACLE study. J. Interv. Card. Electrophysiol. 12, 107–113 (2005).

    Article  Google Scholar 

  3. Go, A. S. et al. Heart disease and stroke statistics—2013 update: a report from the American Heart Association. Circulation 127, e6–e245 (2013).

    Google Scholar 

  4. Zusterzeel, R. et al. Cardiac resynchronization therapy in women: US Food and Drug Administration meta-analysis of patient-level data. JAMA Intern. Med. http://dx.doi.org/10.1001/jamainternmed.2014.2717.

  5. Bristow, M. R. et al. Cardiac-resynchronization therapy with or without an implantable defibrillator in advanced chronic heart failure. N. Engl. J. Med. 350, 2140–2150 (2004).

    Article  CAS  Google Scholar 

  6. Cleland, J. G. et al. The effect of cardiac resynchronization on morbidity and mortality in heart failure. N. Engl. J. Med. 352, 1539–1549 (2005).

    Article  CAS  Google Scholar 

  7. Tracy, C. M. et al. 2012 ACCF/AHA/HRS focused update of the 2008 guidelines for device-based therapy of cardiac rhythm abnormalities: a report of the American College of Cardiology Foundation/American Heart Association task force on practice guidelines and the Heart Rhythm Society. Circulation 126, 1784–1800 (2012).

    Article  Google Scholar 

  8. Simonson, E. et al. Sex differences in the electrocardiogram. Circulation 22, 598–601 (1960).

    Article  Google Scholar 

  9. Yancy, C. W. et al. Influence of patient age and sex on delivery of guideline-recommended heart failure care in the outpatient cardiology practice setting: findings from IMPROVE HF. Am. Heart. J. 157, 754–762.e2 (2009).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. University at Buffalo, School of Medicine and Biomedical Sciences, Buffalo General Medical Centre, 100 High Street, Buffalo, 14203, NY, USA

    Deepika Narasimha & Anne B. Curtis

Authors
  1. Deepika Narasimha
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Anne B. Curtis
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Anne B. Curtis.

Ethics declarations

Competing interests

A.B.C. serves on the medical advisory board for St. Jude Medical and is a consulting cardiologist for Medtronic. She has received speaker's fees from St. Jude Medical and Medtronic. D.N. declares no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Narasimha, D., Curtis, A. Cardiac resynchronization therapy in women. Nat Rev Cardiol 11, 501–502 (2014). https://doi.org/10.1038/nrcardio.2014.113

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrcardio.2014.113

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing