HIV infection is associated with increased risk of acute myocardial infarction (HR 1.48, 95% CI 1.27–1.72), even in patients achieving HIV-1 RNA levels <500 copies per ml (HR 1.39, 95% CI 1.17–1.66), according to a study published in JAMA Internal Medicine. The investigators assessed data for 82,459 individuals who were followed up for a median 5.9 years. Risk estimates were adjusted for Framingham risk factors, comorbidities, and substance use.