The Friedewald equation, which is commonly used to estimate LDL-cholesterol level, assumes a fixed ratio of five between triglycerides and VLDL cholesterol (TG:VLDL-C). Martin et al. have developed and validated a novel method of LDL-cholesterol level estimation, using a variable TG:VLDL-C ratio derived from data obtained from 1,350,908 US adults, adolescents, and children. The model improved the accuracy of LDL-cholesterol level estimation, particularly in classifying LDL-cholesterol concentration <70 mg/dl among individuals with an elevated TG level. If externally validated, Martin et al. believe that “implementation of these findings into clinical practice would be straightforward and at virtually no cost”.