A retrospective analysis of data from men in the US Veterans Affairs system has shown that testosterone therapy is associated with an increased risk of death, myocardial infarction, or stroke. Vigen et al. examined outcomes for 8,709 men with testosterone levels <300 ng/dl who underwent diagnostic coronary angiography. The rate of the composite outcome during the 3 years after angiography was higher in men who received testosterone therapy (n = 1,223) than in those who did not (25.7% vs 19.9%). In a multivariate analysis, testosterone therapy was independently associated with adverse cardiovascular outcomes (HR 1.29, 95% CI 1.04–1.58). Commenting on the study, in which she was not involved, Anne R. Cappola warns “in light of the high volume of prescriptions and aggressive marketing by testosterone manufacturers, prescribers and patients should be wary.”