Abstract
Recent findings have thrust poly(ADP-ribose) polymerases (PARPs) into the limelight as potential chemotherapeutic targets. To provide a framework for understanding these recent observations, we review what is known about the structures and functions of the family of PARP enzymes, and then outline a series of questions that should be addressed to guide the rational development of PARP inhibitors as anticancer agents.
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Acknowledgements
The authors are supported by research funds from a Canada research chair in proteomics, the Canadian Institutes of Health Research (CIHR grants MOP-74648 and IG1-14052), the Cancer Research Society, the Alberta Cancer Board and the National Institutes of Health (NIH grant P50 CA136393-01).
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Rouleau, M., Patel, A., Hendzel, M. et al. PARP inhibition: PARP1 and beyond. Nat Rev Cancer 10, 293–301 (2010). https://doi.org/10.1038/nrc2812
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DOI: https://doi.org/10.1038/nrc2812
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